Dracula
The vampire's power comes with considerable categorical weaknesses. Sunlight produces immediate combustion, holy symbols wielded with faith cause genuine harm, and running water presents navigational barriers. Wooden stakes to the heart induce paralysis if not destruction, and garlic apparently causes genuine discomfort.
These vulnerabilities represent systematic exploitable weaknesses that any informed opponent can research and deploy. Spider-Man's scientific inclination and access to information would certainly reveal these countermeasures within minimal preparation time.
Spider-Man
Spider-Man possesses no categorical vulnerabilities beyond those inherent to enhanced human physiology. He can be harmed by conventional means if attacks successfully connect, though his durability significantly exceeds baseline human capacity. No specific substance or symbol produces disproportionate harm.
His primary vulnerability lies in psychological exploitation, particularly threats to loved ones, and the finite nature of his physical stamina. Unlike the vampire, he cannot sustain combat indefinitely without rest and nutrition.